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The cell contains millimolar concentrations of GSH (up to 10 mM) that is maintained in this reduced form by a cytosolic NADPHdependent reaction catalysed by glutathione reductase
Overall, these findings suggest that targeting IRE1 could be a viable strategy to overcome immune evasion in immune-cold tumors and enhance the efficacy of chemotherapy in TNBC
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Thus treatment with ALCAR during the first 48 hours after HI on postnatal day 7, or after TBI on day 2122 led to long-term protection of the ipsilateral hemisphere and improved behavioral outcome [12, 39]
