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ascorbate and glutathione the heart of the redox hub Heat shock induces cross adaptation to aluminum stress through enhancing ascorbate-glutathione cycle in wheat seedlings The ascorbate–glutathione cycle—a major antioxidant
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10.1016/j.pnpbp.2010.03.005 Prog
Split doses can be helpful, as large amounts of vitamin C can sometimes cause gastrointestinal discomfort

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Nitric oxide ultimately leads to the formation of RNS (reactive nitrogen species) which is known to cause mitochondrial damage and is therefore suggested to be a critical agent in chondrocyte function and apoptosis
