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compared women who proceeded to develop hypertension during pregnancy, including pre-eclampsia and gestational hypertension, with those that remained normotensive throughout pregnancy (n = 55) [100]
25 A predominant etiological factor responsible for the development of DKD is hyperglycemia
In addition, our observation that higher IGF-1 concentration is associated with longer survival is consistent with experimental research, showing that IGF-1 acts as a mitochondrial protector in the ALS cell and mouse model 10
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