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Long-term randomized trials are scarce, and dose-response across diverse populations needs refinement

Using the ZSF1 rat model our results demonstrate that changes in the microbiome occur at an early timepoint in HFpEF progression, before cardiac function is distinctively impaired [8]

Interestingly, the weight loss and metabolic improvement observed in gastric bypass (RYGB) involve activation of the sympathetic tonus in the gut, which was associated with decreased CB1 and activation of WAT thermogenesis, a phenomenon known as browning that increases energy expenditure and resting metabolic rate (Ye et al., 2020)

Diabetes Prevention Program Research Group Impact of lifestyle intervention and metformin on health-related quality of life: the Diabetes Prevention Program randomized trial J Gen Intern Med 27 12: 1594-601