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While sustained astrocyte activation is often seen as detrimental, recent evidence highlights their reparative roles, including HO-1 production, metabolic support to OPCs, and recruitment of phagocytes for myelin debris clearance ( 4.2 Conclusion and future perspectives In summary, this study provides the first integrative temporal characterization of gutbrain axis components in the CPZ model of reversible demyelination

Stress, fatigue and brain fog as well as reduced physical stamina are common side effects of vitamin B12 deficiency

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