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Since the cytoplasmic concentration of GSH is usually two or three orders of magnitude greater than that of GSSP, a minimal percentage of oxidation leading to the production of GSSP causes a massive artificial alteration of their levels

556 Consequently, researchers believe that HIF-1 may serve as a mechanism for cells to rapidly respond to acute hypoxia, whereas HIF-2 may be more relevant in chronic hypoxic responses

In addition, modifying the C terminus of IGF-1 with the addition of PEG may increase the peptide's potential impact on tissues

But I wouldnt option it to an actor who is usually who wants it or a producer, because they could just hand it to anybody