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96 Studies have shown that this process is dependent on intracellular complement component (C) 5aR1 signaling, where C5a binds to receptors on the mitochondria, triggering ROS production and providing one of the necessary activation signals for inflammasome assembly and IL-1 secretion, especially in response to sterile inflammation induced by cholesterol crystal exposure

AP-3-dependent trafficking and disease: the first decade

Image Source: freepik.com Acetyl-L-carnitine, a form of L-carnitine, may support brain health