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Mild allergic reactions, limited to localized redness and itching, can often be managed at home with over-the-counter hydrocortisone cream and oral antihistamines

That process is slow, and for some people it is not very efficient

Clinical translation requires human CSF pharmacokinetic assays to prove BBB bypass, a rigorous dose-escalation Phase I trial to establish a safe human NOAEL for chronic dosing, and an RCT utilizing precise neurocognitive testing (e.g., MoCA) to confirm that murine transcriptomic shifts yield functional neuroprotection in humans

However, this study lacked a control group or placebo comparison, and the sample size was very small