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There are, however, a number of major technological challenges involved in translating these reactions from laboratory scale to industrial scale, including catalyst stability, reaction kinetics, and bioreactor design [502,503]

Air pressure equalization Lyophilized peptide vials are often sealed under reduced pressure or vacuum
Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Division of Vector-Borne Diseases (DVBD)

Leslie 2004
