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It is important to recognise that marketing claims linking B12 supplementation directly to weight loss are not supported by robust clinical evidence from UK or international health authorities

Also, those cells use glucose as a source for TCA cycle anaplerosis, which can sufficiently provide -ketoglutarate for glutamate and glutamine synthesis

In contrast, DFP treatment significantly decreased Fe 2+ levels in optic nerve tissue, downregulated TFR1 and Iba-1 expression, and inhibited iron deposition, ferroptosis, microglial activation, and astrocyte proliferation, thereby reducing myelin loss and optic nerve damage in MS mice (Rayatpour et al., 2022)

B., Zeghoud S., et al