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Severe liver disease can include inflammation of the liver (chronic active hepatitis), inflammation of the bile ducts (primary sclerosing cholangitis), which narrow and eventually close, and replacement of functional liver tissue with scar tissue (cirrhosis)

Pancolitis describes involvement of the entire colon, extending from the rectum to the cecum

Cobalt sensitivity reactions can result in different symptoms, such as chronic or subacute allergic contact dermatitis, which can occur immediately or up to 72 hours after administration, but the likelihood of a cobalt allergy is low and affects between 1% and 3% of the general population

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