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Therefore, Cu 2+ coordination by the histidine residues in PrP is central to either neuroprotection or neurodegeneration

55 WuY.XiaY.HuA.XiongG.WuW.ShiL.et al

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However, it increased heart rate, cardiac output, and induced myocardial degeneration in mice and thus was terminated as a preclinical candidate (Yau et al., 2017)
