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2.1 Orchestrating the non-immune cells in the tumor microenvironment with peptides 2.1.1 Peptide mediation in cancer-associated fibroblast-induced extracellular matrix remodeling Cancer cells recruit CAFs, which are crucial in shaping the malignant TME
Zhao et al., 2025) that MSCs can not only directly differentiate into nucleus pulposus-like cells, replenishing the missing cell population (Li et al., 2025), but also play a key role through paracrine actions: on one hand, by secreting growth factors (such as TGF-, IGF-1) to activate anabolic pathways and promote ECM synthesis (Tang et al., 2025)
[DOI] [PMC free article] [PubMed] [Google Scholar] Shook B.A., Wasko R.R., Rivera-Gonzalez G.C., Salazar-Gatzimas E., Lpez-Girldez F., Dash B.C., et al
Per FY2026 ICD-10-CM Official Guidelines, the 6th character for complications is required when documented
