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Anxiolytic-like effect of natural product 2-hydroxy-3,4,6-trimethoxyacetophenone isolated from Croton anisodontus in adult zebrafish via serotonergic neuromodulation involvement of the 5-HT system

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However, as described earlier, the significance of this putative Na + -binding site for MurJ function or structure could not be determined because mutations altering most of the coordination sphere residues led to significant or complete loss of expression, suggesting that the Na + -binding site might serve a structural role