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In a mouse model of cigarette smoke solutioninduced COPDlike injury, inhalation of 42% H 2 gas for 75 min twice daily over 9 weeks resulted in a 100% survival rate, compared with 80% in the untreated group

3.3 Combination strategies for enhanced anti-tumor efficacy Modulating the gut microbiotabile acid (BA) axis offers a promising strategy to enhance the efficacy of existing cancer therapies by reshaping host immunity and TIME

Animal model studies have preliminarily revealed that Clostridium colonization can curtail the overgrowth of pro-inflammatory microbiota, restore the intestinal mucosal barrier, and limit systemic translocation of bacterial LPS, ultimately reestablishing gut microbial homeostasis (206, 207)

Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay