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In this study, we investigated the effects of dysregulated glutathione homeostasis, a principal feature of oxidative stress, on TNF-induced hepatotoxicity and its mechanistic implications in NAFLD progression

11.8 The road ahead: toward precision microbiome-based therapies Advances in biotechnology and bioinformatics are expected to deepen our understanding of probiotic mechanisms of action, accelerate the discovery of novel candidate organisms and prebiotic substrates, and enhance the reproducibility and comparability of both laboratory and clinical studies (536)

This abnormal load distribution further impairs the mechanical function of the disc, transferring excessive stress to the annulus fibrosus, leading to its damage and contributing to pain 6,26