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However, in line with our observation of elevated ser/gly synthesis in HIF2 KO NSCLC cells, HIF2 deficient renal cell carcinoma (RCC) cells showed upregulation of ser/gly synthesis pathway and presented enhanced sensitivity to the inhibition of this pathway using the phosphoglycerate dehydrogenase (PHGDH) inhibitor NCT-503 [57]
Immune cells are outstanding models for studying the metabolic function of cells (163)
[DOI] [PubMed] [Google Scholar] Kelly HW, Van Natta ML, Covar RA, Tonascia J, Green RP, Strunk RC, et al
2018;314:L1731