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o The Phase 3b STEP UP trial showed that a 7.2mg dose of semaglutide achieved an 18.3% placebo-adjusted body weight reduction, fiercely competing with tirzepatide's reported 17.8% over the same timeframe

It is debated whether and to what extent neurons depend on astrocytic lactate, given evidence of their autonomous glycolytic capacity in specific contexts (Tang, 2018

Pignatelli P, Loffredo L, Martino F, Catasca E, Carnevale R, Zanoni C, Del Ben M, Antonini R, Basili S, Violi F

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