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Suppression of IL-10/STAT3 or TGF-/SMAD-dependent antioxidant circuits enables the restoration of lipid peroxidation susceptibility in adjacent tumor cells (107)

Regarding to immune response, oxaliplatin-treated neurons release significant amounts of pro-inflammatory cytokines, mainly TNF- and IL-6, whereas prostaglandin E2 levels were significantly higher in macrophagues exposed to the platinum compound than in control cells

J Agric Food Chem 59:58355841 Feng PCC, CaJacob CA, Martino-Catt SJ, Cerny RE, Elmore GA, Heck GR, Huang J, Kruger WM, Malven M, Miklos JA, Padgette SR (2010) Glyphosate-resistant crops: developing the next generation products

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
