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The intratumor activation of C/EBP- LIP further enhanced the responses elicited by the chloroquine /bortezomib/doxorubicin combination, confirming that C/EBP- LIP and its downstream effectors (such as CHOP and caspase 3) are critical factors in overcoming doxorubicin resistance

Simultaneously, pyroptosis markers NLRP3, GSDMD, caspase1, IL-1 and IL-18were all significantly upregulated, indicating pyroptosis occurred in MCT induced PH rats (Fig

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Canas PM, Duarte JM, Rodrigues RJ, Kfalvi A, Cunha RA (2009) Modification upon aging of the density of presynaptic modulation systems in the hippocampus