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Description
Busulfan with having two methanesulfonate groups, attached to two ends of a butane chain, hydrolyzes and releases extremely reactive positively charged carbonium ions, which react with the guanine molecules in cell's DNA, resulting in DNA interstrand crosslinks
As early diagnosis and treatment prevent development of metabolic crisis and cardiomyopathy, most NBS-diagnosed patients are expected to live a normal life span free of symptoms
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doi: 10.7326/0003-4819-151-4-200908180-00135
