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Dai C., et al.Loss Of Tumor Suppressor Nf1 Activates Hsf1 To Promote Carcinogenesis

Highly reactive, NO has a short half-life of just a few seconds and diffuses easily across cellular membranes, making it an ideal transient paracrine and autocrine signaling molecule (Stryer 1995)

doi: 10.1210/endrev/bnad016 8 Dos-SantosRGomez-VieitesCFernndezDFernndezIVilasAPrez-PampnEet al

These nerve-related changes can occur even without anemia being present, which means standard blood counts alone may not catch a developing deficiency
