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CGA alleviates liver inflammation during non-alcoholic steatohepatitis (NASH) progression by blocking the LPS-TLR4-MyD88 signaling pathway via direct binding to MyD88 and by activation of Nrf2/PPAR signaling [173]
Figure EV4 Go annotation and pathway analysis of the differentially expressed genes in tumors derived from subcutaneous HCC mouse model receiving different treatments
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These trials have not explored the impact of this supplementation on the gut microbiome but have demonstrated beneficial effects of parenteral lactate [119,120,121] and oral [122, 123] or parenteral BCAAs [124, 125]
