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Chronic meth use is also associated with: Cardiovascular strain (heart problems, high blood pressure) Severe dental problems (meth mouth) Skin issues from scratching Cognitive changes affecting memory and decision-making Mental health symptoms like chronic anxiety, paranoia, or depression For LGBTQIA+ folks, substance use patterns can be connected to experiences of minority stress, internalized stigma, discrimination in healthcare settings, or social environments where drug use is normalized (like party scenes or chemsex situations)

In line with this notion, LIPL-1, -2, -5, and -7, and LIPS-4, -14, and -17 expression is altered in aging worms and/or in long-lived mutants (Budovskaya et al., 2012

Mol Biol Cell 18: 9951008

For patients who cannot maintain onceweekly dosing (perhaps due to financial constraints), decreasing frequency is likely preferred to simply discontinuing their GLP1 therapy, since complete discontinuation typically results in regaining two thirds of the lost weight within 1 year