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As we identified GPX4 as a functional target of three out of four senolytic chloroacetamides, we wanted to understand how widely senolytic electrophilic compounds might induce ferroptosis
[DOI] [PubMed] [Google Scholar] 26.Schotanus BA, van den Ingh TS, Penning LC
By regulating glutathione S-transferase (GST) and intracellular glutathione (GSH) levels, Nrf2 controls the level of ROS in the cell induced by external stressors such as xenobiotic or electrophilic stress
