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Glutathione and Immune Modulation Depleted intracellular glutathione has been associated with shifts in T-helper cell balance, specifically a Th1/Th2 imbalance, and increased pro-inflammatory cytokine signalling, including elevated tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6)

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The anemia develops due to the trapping of folate in the reduced form ( N 5 -methyl-THF) which results in depletion of the active folate pool