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Similarly, PAT-1251 would inhibit both LOXL2 and LOXL3 at 10 M (IC 50 (LOXL2) = 0.87 M, IC 50 (LOXL3) = 1.38 M), but inhibit less than 10% inhibition of diamine oxidases (hDAO) and monoamine oxidase (hMAO) 41
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This common tripeptide exists in high concentrations throughout cell compartments and keeps redox balance through several mechanisms
ORegan, The PI3K/AKT/mTOR pathway in breast cancer: targets, trials and biomarkers
