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Author Contributions Conceptualization and design, D.M., J.C.D
With respect to the polyamines, spermidine is the only molecule in this family that has been shown to exhibit these effects
importantly, cumulative exposure (measured in pack-years) was strongly associated with fibrosis severity, with each additional pack-year tripling the likelihood of advanced fibrosis (adjusted OR per pack-year: 3.2
NF-kB is a switch that can turn on many inflammatory genes
