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In sarcoidosis patients, IFN- may exert anti-apoptotic effects on macrophages by inducing the expression of the cyclin-dependent kinase inhibitor p21/Waf1, thereby contributing to the persistence of lung inflammation [122]

The effect of altered iron homeostasis on metabolic impairments has also been studied in mouse models

Workers with prolonged exposure to 4-aminobiphenyl exhibit significantly higher bladder cancer rates compared to the general population (Tao et al., 2013

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