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LC, liquid chromatography

BAY-1082439, a chemical molecule undergoing phase I clinical trials in patients with advanced cancer, can efficiently inhibit the expression of P-gp and BCRP by selectively inhibiting PI3K 110 and 110, and slightly suppress the efflux effect of P-gp and BCRP (118)

Alterations in DNA methylation patterns can influence gene expression and cellular processes within the cardiovascular and neurological systems, contributing to the pathogenesis and progression of these diseases (21, 22)

Pande and Flora [69] reported that a combination of lipoic acid and thiol chelator was able to alleviate lead toxicity, and in particular, it reduced oxidative stress and lead levels in the brain