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Description
Au4 cluster inhibits human thioredoxin reductase activity via specifically binding of Au to Cys189
Heme groups consist of a central iron atom in a coordinated binding to a protoporphyrin, composed of four pyrrole rings
J Alzheimers Dis : JAD 90:585
Therefore, DHODH has emerged as a potential regulatory hub, where its inhibition may enhance ferroptotic cell death, offering a novel angle for therapeutic intervention, particularly in cancers such as pancreatic adenocarcinoma (175) and breast cancer (176), where certain cells show resistance to other forms of cell death (171,177)
