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pmid:36002205Abstract/FREE Full TextGoogle Scholar

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

The KEGG pathway Steroid biosynthesis (adjusted p = 1.76 10 9 ) showed uniform down-regulation across all 7 participating genes (Figure 2