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As mentioned previously, several studies have reported that brain GSH levels are reduced following TBI and genetic variations in GSH-dependent, peroxide/electrophile-detoxifying enzymes, such as glutathione-S-tranferase-4 and glutathione peroxidase-1, can sensitize mice and rats to brain injury induced by TBI (Tyurin et al., 2000

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A case-control study involving 4,995 cancer patients and 4,972 controls from a Chinese population found that a variant in the Caspase-8 gene was associated with reduced susceptibility to several cancers, including lung, esophageal, gastric, colorectal, cervical, and breast cancers

2020;243 doi: 10.1016/j.lfs.2020.117277