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There was a similar trend of fibrinogen level decrease from day 1 to 21 in the placebo group ( p = 0.057)

However, combined-use research introduces complexity: overlapping MC1R activation could produce additive or saturating effects at the receptor level, and it becomes difficult to attribute specific outcomes to one compound versus the other

If results are minimal, the course can be extended until the desired effect is achieved, but no longer than 30 consecutive days