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10.1073/pnas.1012496107 185 PatelD.AnilkumarS.ChattarjiS.BuwaldaB

in practice, 70% to 85% of FIMs that reach final IC are approved , since the prior approval gates have already filtered out the weakest candidates

Antibiotics profoundly disrupt gut microbiota, transiently reducing IS/pCS production for weeks post-treatment, and phosphate binders such as sevelamer bind IS in the gut, lowering circulating levels independent of microbial production changes
