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One mechanism involves homocysteine interfering with how cells use oxygen, which results in a build up of damaging free radicals

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Initial colon defect presentation at 4 weeks following fistula creation by anastomosis between the skin and colon defect (c, middle)

NADH levels can be increased in mitochondria by malate-aspartate and the glycerol-3-phosphate redox shuttles 14
