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doi: 10.1152/ajpendo.00287.2009
Notably, both MG and 7-HMG display G proteinbiased agonism at MOR, preferentially activating G-protein pathways over -arrestin recruitment, a signaling profile that has been hypothesized to underlie improved therapeutic outcomes (Kruegel et al., 2016

Sagar M, Reifler K, Rossi M, Miller NS, Sinha P, White LF, et al
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