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Ultraviolet B irradiation induces skin accumulation of plasmacytoid dendritic cells: a possible role for chemerin

doi: 10.1093/protein/13.10.703

In particular, cAMP-specific PDE4 type is widely present in immune cells including neutrophils and contributes to neutrophil-mediated lung inflammation (Phillips, 2020), apremilast for psoriasis (Queiro Silva et al., 2020), and crisaborole for atopic dermatitis (Hashim et al., 2020)

Despite the differences in their stimuli, both pathways share common mechanistic features, most notably the production of ROS via respiratory burst oxidase homologs (RBOHs) and subsequent activation of redox-sensitive signaling cascades