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Description
Brachyury and SMAD signalling collaboratively orchestrate distinct mesoderm and endoderm gene regulatory networks in differentiating human embryonic stem cells
PMID: 24518091
doi: 10.1134/S1990519X07010063
The peptide activates extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation in a dose-dependent manner, leading to nuclear translocation and activation of transcription factors including c-Fos, c-Jun, and early growth response-1 (Egr-1) that drive expression of genes involved in cell growth, migration, and angiogenesis
