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After binding with PERK, TMAO selectively activates PERK-mediated UPR, thereby promoting metabolic dysfunction ( Of note, TMAO in the pathogenesis of Alzheimers disease (AD) indicated that PERK is not the only mechanism by which TMAO induces UPR

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[DOI] [PubMed] [Google Scholar] 48.Miecz D, Januszewicz E, Czeredys M, Hinton BT, Berezowski V, Cecchelli R, Nalecz KA
