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The use of commercially available, pre-activated media is recommended to save time and avoid the use of the potentially hazardous reagents that are required in some cases [4]

Thus, upon careful selection of the MOA, the inclusion of ferroptosis-inducing agents within a clinically relevant treatment protocol is feasible and can outperform standard-of-care chemotherapy in high-risk NB

The E 2 subunit contains a lipoic acid residue which is extremely important for catalysis of substrate oxidation and decarboxylation but is also highly amenable to redox modifications

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