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While some therapeutic approaches have shown promise in limiting renal injury and fibrosis in clinical trials [2, 6], the overall clinical efficacy remains limited

Mutations in the Rb pathway include deletions in CDKN2A , which encodes p16, and amplifications of CDK4

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Additionally, inhibition of SLC1A5-mediated glutamine transport by knockdown of SLC1A5 or adding SLC1A5 inhibitor L--glutamyl-p-nitroanilide (GPNA) attenuates mTOR activation and proliferation of breast cancer cells, and these inhibitory effects are more prominent in TNBC tumor cells compared to luminal subtypes (88)