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IV administration might be chosen if you are already on IV fluids or need a very rapid correction of vitamin levels

The combination of the amylin analogue pramlintide and the recombinant human leptin metreleptin caused significant weight reductions ( - 11.5kg) in comparison with monotherapy in a 24-week phase 2 clinical trial [248]

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Besides the additional problems of nausea, diarrhea, and high heart rate, another concerning issue with GLP-1 agonists is the loss of muscle mass in those on the drug