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Although ozone is an agent with a high disinfectant effect, ozone does not have such an effect in vivo.18, Factors Affecting Dose Systemic Methods (Major Autohemotherapy, rectal, insufflation) Loco-Systemic Methods (Major and Minor blood application) Local Methods (such as cream, solution, bagging, sauna, etc.) Combined Methods (The above methods are used together) MAHT Therapeutic Doses: 1-80 mic/ml Starting with 5 mic/ml and increasing to 30-40 mic/ml