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As ART alone is insufficient to fully suppress HIV-1 replication, including the transcription and translation of the HIV-1 provirus, there is a critical need to develop new brain-penetrat agents that can effectively target both the CNS and the peripheral immune system to silence HIV-1 and reduce the risk of neuroinflammation

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doi: 10.1111/j.1471-4159.2012.07756.x

Until we have robust clinical data from well-designed human trials, any claims about the definitive efficacy of BPC-157 and TB-500 for post-surgical recovery must be viewed as speculative at best
