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The brain is then able to launch a series of behavioral and physiologic reactions together named the sickness behavior, which include, fever, reduced appetite, weariness, social withdrawal, and disturbed sleep patterns

In metabolomics, metabolite set enrichment analysis is used to identify the altered metabolite sets (metabolic pathways) associated with phenotypes of interest, e.g., presence of fatigue, using algorithms which is run on a general metabolite network constructed based on public databases, i.e., KEGG (Kyoto Encyclopedia of Genes and Genomes) in the present study 57,58,59

Lan YL, Wang X, Xing JS, Yu ZL, Lou JC, Ma XC, et al

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