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Other Emerging Treatment Strategies In addition to vitamins and minerals, pharmacological therapeutic options have been tested and multiple are currently in phase 3 trial review [68,69]

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doi:10.1128/JB.187.17.5901-5909.2005

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Further experiments revealed that hydrogen-induced Nrf2 can directly bind to NF-B p65, interfering with its DNA-binding ability to pro-inflammatory gene promoters while also suppressing the release of inflammatory mediators such as HMGB1 and TNF-, thereby truncating the positive feedback loop of IKK

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