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Color reflects that evidence, amber for a real but limited or non-brain signal, gray for little, untested, or no measured effect

Children aged 412 years were diagnosed with ASD according to DSM criteria, both boys and girls were included, and the study explicitly excluded participants with major psychiatric comorbidities such as ADHD, depressions, bipolar disorder, anxiety disorders, epilepsy, severe intellectual disabilities, or recent antipsychotic use, ensuring relative homogeneous sample focused on irritability

Some interactions are similar between the subunits, such as Ile32 interacting with the adenine group

Fast synaptic action by glutamate is mediated via ionotropic receptors, which include a heterogenous family of tetrameric ligand-gated channels classified based on their structural homology and response to pharmacological agonists