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Therefore, the subsequent experiments were used to determine whether Sirt1 affected the nuclear translocation of Gli-1 and the expression levels of components of the Shh signaling pathway, such as Shh, Ptc-1, Smo and Gli-1
Mukai, N., Nakanishi, T., Shimizu, A., Takubo, T
Synthetic analogues of PTH, such as Teriparatide (a recombinant form of PTH), have been approved by the FDA for human use and are used clinically to treat osteoporosis, a condition characterised by weak and brittle bones
A continuous exposure might be necessary for chronic studies, whereas acute investigations might only require a single dose
