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Berberine also induces apoptosis via the mitochondrial pathway, promoting the release of cytochrome c from mitochondria, activating caspase-8, 9, and subsequent caspase-3 cascades, and triggering apoptosis by inhibiting the expression of Bcl-2 while increasing pro-apoptotic proteins (85)

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doi: 10.1155/2016/4579149

Pioneering in vivo studies with 203 Hg showed that the brain uptake of MeHg in rats is enhanced by continuous L-cysteine infusion (Aschner and Clarkson, 1987)